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Topographic wiring of the retinotectal connection in zebrafish
Author(s) -
Kita Elizabeth M.,
Scott Ethan K.,
Goodhill Geoffrey J.
Publication year - 2015
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.22256
Subject(s) - zebrafish , biology , neuroscience , visualization , projection (relational algebra) , fish <actinopterygii> , connection (principal bundle) , anatomy , computer science , artificial intelligence , genetics , gene , structural engineering , algorithm , fishery , engineering
The zebrafish retinotectal projection provides an attractive model system for studying many aspects of topographic map formation and maintenance. Visual connections initially start to form between 3 and 5 days postfertilization, and remain plastic throughout the life of the fish. Zebrafish are easily manipulated surgically, genetically, and chemically, and a variety of molecular tools exist to enable visualization and control of various aspects of map development. Here, we review zebrafish retinotectal map formation, focusing particularly on the detailed structure and dynamics of the connections, the molecules that are important in map creation, and how activity regulates the maintenance of the map. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 75: 542–556, 2015