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Signaling to the microtubule cytoskeleton: An unconventional role for C a MKII
Author(s) -
McVicker Derrick P.,
Millette Matthew M.,
Dent Erik W.
Publication year - 2015
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.22227
Subject(s) - synaptic plasticity , biology , cytoskeleton , microbiology and biotechnology , neuroscience , microtubule , metaplasticity , dendritic spine , neuroplasticity , actin cytoskeleton , actin , biochemistry , cell , receptor , hippocampal formation
Synaptic plasticity is a hallmark of the nervous system and is thought to be integral to higher brain functions such as learning and memory. Calcium, acting as a second messenger, and the calcium/calmodulin dependent kinase CaMKII are key regulators of neuronal plasticity. Given the importance of the actin and microtubule (MT) cytoskeleton in dendritic spine morphology, composition and plasticity, it is not surprising that many regulators of these cytoskeletal elements are downstream of the CaMKII pathway. In this review, we discuss the emerging role of calcium and CaMKII in the regulation of MTs and cargo unloading during synaptic plasticity. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 75: 423–434, 2015