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The Wnt cries many: Wnt regulation of neurogenesis through tissue patterning, proliferation, and asymmetric cell division
Author(s) -
Bielen Holger,
Houart Corinne
Publication year - 2014
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.22168
Subject(s) - wnt signaling pathway , neurogenesis , biology , cell fate determination , neural stem cell , neuroscience , cell division , microbiology and biotechnology , corticogenesis , asymmetric cell division , cell cycle , cell polarity , neural development , cell growth , stem cell , transcription factor , cell , signal transduction , progenitor cell , genetics , gene
During early development Wnt signaling has a key role in patterning the prospective nervous system by regulation of cell fate specification, cell polarity, and cell migration. Wnt also coordinates the formation of neural circuits on multiple levels such as transcription, cell cycle, and asymmetric cell division. Here we review the latest findings addressing the role of canonical Wnt/β‐catenin signaling during developmental and adult neurogenesis; exploring the connection of in vivo data to the recently described Wnt‐driven asymmetric stem cell division in vitro . Understanding how Wnt orchestrates these processes in a spatiotemporal manner during corticogenesis will be of crucial importance for the development of new strategies to regenerate neuronal circuits. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 74: 772–780, 2014