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More than one ring to bind them all: Recent insights into the structure of the axon
Author(s) -
Gallo Gianluca
Publication year - 2013
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.22100
Subject(s) - biology , axon , cytoskeleton , actin , neuroscience , axon guidance , actin cytoskeleton , growth cone , protein filament , theme (computing) , regulator , microbiology and biotechnology , genetics , cell , computer science , gene , operating system
This brief review outlines recent developments in the understanding of the ultrastructural organization of the axonal and growth cone actin filament cytoskeleton. A novel form of structural organization has arisen as a regulator of the actin cytoskeleton: ring‐like structures. Rings may represent a conserved functional theme exhibited by diverse molecular systems and have implications for the understanding of the axon in development, maturity, and disease. © 2013 Wiley Periodicals, Inc. Develop Neurobiol 73:799–805, 2013