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Adult periventricular neural stem cells: Outstanding progress and outstanding issues
Author(s) -
Chojnacki Andrew,
Cusulin Carlo,
Weiss Samuel
Publication year - 2012
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.22029
Subject(s) - neuroscience , neural stem cell , biology , lateral ventricles , stem cell , population , medicine , microbiology and biotechnology , environmental health
Twenty years have past since the existence of neural stem cells (NSCs) within the walls of the adult lateral ventricles was discovered. During this period of time, great strides have been made in every facet of our understanding of this adult periventricular NSC population. In this review, some of the fields' major advancements regarding the nature and function of adult periventricular NSCs are examined. We bring attention to issues related to NSC identity, potential, and the role of Notch signaling in regulating quiescence and activation that warrant further investigation. Progress in the understanding of human adult NSCs will aid in the development of tools required to advance therapies not only for brain repair after injury or disease but may also lead to novel therapeutics for brain tumors. © 2012 Wiley Periodicals, Inc. Develop Neurobiol 72: 972–989, 2012