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Stem cell maintenance in the adult mammalian hippocampus: A matter of signal integration?
Author(s) -
Schwarz Tobias J.,
Ebert Birgit,
Lie D. Chichung
Publication year - 2012
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.22026
Subject(s) - dentate gyrus , hippocampal formation , neural stem cell , neuroscience , biology , neurogenesis , stem cell , hippocampus , granule cell , microbiology and biotechnology
The continuous generation of new neurons from stem cells in the hippocampal dentate gyrus is considered an important contributor to hippocampal plasticity. A prerequisite for the life‐long generation of new dentate granule neurons is the maintenance of the neural stem cell pool. A number of essential molecular regulators and signals for hippocampal neural stem cell maintenance have been identified, but how these pathways interact to prevent precocious differentiation or exhaustion of the stem cell pool is currently unknown. Here, we summarize the current knowledge on the molecular regulation of the hippocampal stem cell pool and discuss the possibility that signal integration through Notch signaling controls stem cell maintenance in the adult hippocampus. © 2012 Wiley Periodicals, Inc. Develop Neurobiol 72: 1006–1015, 2012