Premium
The multiple roles of the cyclin‐dependent kinase inhibitory protein p57 KIP2 in cerebral cortical neurogenesis
Author(s) -
Tury Anna,
MairetCoello Georges,
DiCiccoBloom Emanuel
Publication year - 2012
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.20999
Subject(s) - neurogenesis , biology , cyclin dependent kinase , cell cycle , microbiology and biotechnology , cyclin , kinase , cyclin e , cell migration , cell growth , cell , neuroscience , biochemistry
The members of the CIP/KIP family of cyclin‐dependent kinase (CDK) inhibitory proteins (CKIs), including p57 KIP2 , p27 KIP1 , and p21 CIP1 , block the progression of the cell cycle by binding and inhibiting cyclin/CDK complexes of the G1 phase. In addition to this well‐characterized function, p57 KIP2 and p27 KIP1 have been shown to participate in an increasing number of other important cellular processes including cell fate and differentiation, cell motility and migration, and cell death/survival, both in peripheral and central nervous systems. Increasing evidence over the past few years has characterized the functions of the newest CIP/KIP member p57 KIP2 in orchestrating cell proliferation, differentiation, and migration during neurogenesis. Here, we focus our discussion on the multiple roles played by p57 KIP2 during cortical development, making comparisons to p27 KIP1 as well as the INK4 family of CKIs. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 821–842, 2012