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Dopaminergic and noradrenergic circuit development in zebrafish
Author(s) -
Schweitzer Jörn,
Löhr Heiko,
Filippi Alida,
Driever Wolfgang
Publication year - 2012
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.20911
Subject(s) - zebrafish , dopaminergic , danio , neuroscience , catecholaminergic , biology , vertebrate , dopamine , spinal cord , parkinson's disease , catecholaminergic cell groups , disease , gene , genetics , medicine
Dopaminergic and noradrenergic neurons constitute some of the major far projecting systems in the vertebrate brain and spinal cord that modulate the activity of circuits controlling a broad range of behaviors. Degeneration or dysfunction of dopaminergic neurons has also been linked to a number of neurological and psychiatric disorders, including Parkinson's disease. Zebrafish ( Danio rerio ) have emerged over the past two decades into a major genetic vertebrate model system, and thus contributed to a better understanding of developmental mechanisms controlling dopaminergic neuron specification and axonogenesis. In this review, we want to focus on conserved and dynamic aspects of the different catecholaminergic systems, which may help to evaluate the zebrafish as a model for dopaminergic and noradrenergic cellular specification and circuit function as well as biomedical aspects of catecholamine systems. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 256–268, 2012