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Expression and actions of transcription factors in adult hippocampal neurogenesis
Author(s) -
Hodge Rebecca D.,
Hevner Robert F.
Publication year - 2011
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.20882
Subject(s) - neurogenesis , subgranular zone , biology , subventricular zone , neuroscience , progenitor cell , hippocampal formation , dentate gyrus , progenitor , olfactory bulb , embryonic stem cell , rostral migratory stream , transcription factor , microbiology and biotechnology , stem cell , central nervous system , genetics , gene
Neurogenesis in the adult brain, a process once thought to be essentially absent, has now been demonstrated to occur throughout adult mammalian life within several brain regions. Adult neurogenesis normally occurs only within the subventricular zone (SVZ) bordering the lateral ventricles and the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG). Neurogenic progenitors within these regions produce distinct neuron types, with progenitors in the SGZ giving rise to glutamatergic neurons that populate the DG granule cell layer and those within the SVZ producing neurons destined for the olfactory bulb. In this review, we highlight recent research on transcription factor expression and function during adult hippocampal neurogenesis. In this regard, recent evidence indicates that adult neurogenesis replicates important aspects of progenitor cell development in the embryonic brain. Specifically, work from our laboratory and others indicates that transcription factor cascades active in progenitor cells during neurogenesis in the embryonic cerebral cortex are also activated in adult hippocampal progenitor cells, where they play an important role in determining neuronal fate and regulating progenitor cell proliferation and maintenance. These findings suggest thatconserved transcription factor cascades regulate genetic programs that delineate progenitor cell lineages and control progenitor cell proliferation and differentiation. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 71:680–689, 2011