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The role of selective transport in neuronal polarization
Author(s) -
Namba Takashi,
Nakamuta Shinichi,
Funahashi Yasuhiro,
Kaibuchi Kozo
Publication year - 2011
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.20876
Subject(s) - biology , axon , neuroscience , microtubule , axoplasmic transport , neurite , axon guidance , microbiology and biotechnology , biochemistry , in vitro
Neurons are functionally and morphologically polarized and possess two distinct types of neurites: axons and dendrites. Key molecules for axon formation are transported along microtubules and accumulated at the distal end of the nascent axons. In this review, we summarize recent advances in the understanding of the mechanisms involved in selective transport in neurons. In addition, we focus on motor proteins, cargo, cargo adaptors, and the loading and unloading of cargo. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 445–457, 2011