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Imaging circuit formation in zebrafish
Author(s) -
Nikolaou Nikolas,
Meyer Martin P.
Publication year - 2012
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.20874
Subject(s) - zebrafish , biology , neuroscience , biological neural network , neuronal circuits , neural development , synapse , nervous system , synapse formation , cognitive science , psychology , genetics , gene
The study of nervous system development has been greatly facilitated by recent advances in molecular biology and imaging techniques. These approaches are perfectly suited to young transparent zebrafish where they have allowed direct observation of neural circuit assembly in vivo . In this review we will highlight a number of key studies that have applied optical and genetic techniques in zebrafish to address questions relating to axonal and dendritic arbor development, synapse assembly and neural plasticity. These studies have revealed novel cellular phenomena and modes of growth that may reflect general principles governing the assembly of neural circuits. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 346–357, 2012