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Neuronal polarity in C. elegans
Author(s) -
Ou ChanYen,
Shen Kang
Publication year - 2011
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.20858
Subject(s) - polarity (international relations) , biology , neuroscience , biological neural network , cell polarity , neuron , axon , bursting , caenorhabditis elegans , optogenetics , dendrite (mathematics) , gene , genetics , cell , geometry , mathematics
Neuronal polarity sets the foundation for information processing and signal transmission within neural networks. However, fundamental question of how a neuron develops and maintains structurally and functionally distinct processes, axons and dendrites, is still an unclear. The simplicity and availability of practical genetic tools makes C. elegans as an ideal model to study neuronal polarity in vivo . In recent years, new studies have identified critical polarity molecules that function at different stages of neuronal polarization in C. elegans . This review focuses on how neurons guided by extrinsic cues, break symmetry, and subsequently recruit intracellular molecules to establish and maintain axon‐dendrite polarity in vivo . © 2010 Wiley Periodicals, Inc. Develop Neurobiol 71: 554–566, 2011