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Cholecystokinin: A multi‐functional molecular switch of neuronal circuits
Author(s) -
Lee Soo Yeun,
Soltesz Ivan
Publication year - 2010
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.20815
Subject(s) - cholecystokinin , neuroscience , biology , neuropeptide , neuronal circuits , biological neural network , neurotransmission , premovement neuronal activity , nerve net , receptor , biochemistry
Cholecystokinin (CCK), a peptide originally discovered in the gastrointestinal tract, is one of the most abundant and widely distributed neuropeptides in the brain. In spite of its abundance, recent data indicate that CCK modulates intrinsic neuronal excitability and synaptic transmission in a surprisingly cell‐type specific manner, acting as a key molecular switch to regulate the functional output of neuronal circuits. The central importance of CCK in neuronal networks is also reflected in its involvement in a variety of neuropsychiatric andneurological disorders including panic attacks and epilepsy. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 71: 83–91, 2011