Premium
Assembly and activation of neurotrophic factor receptor complexes
Author(s) -
Simi Anastasia,
Ibáñez Carlos F.
Publication year - 2010
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.20773
Subject(s) - neurotrophic factors , biology , neuroscience , receptor , neurotrophin , functional diversity , brain derived neurotrophic factor , function (biology) , diversity (politics) , microbiology and biotechnology , biochemistry , ecology , sociology , anthropology
Neurotrophic factors play important roles in the development and function of both neuronal and glial elements of the central and peripheral nervous systems. Their functional diversity is in part based on their ability to interact with alternative complexes of receptor molecules. This review focuses on our current understanding of the mechanisms that govern the assembly and activation of neurotrophic factor receptor complexes. The realization that many, if not the majority, of these complexes exist in a preassembled form at the plasma membrane has forced the revision of classical ligand‐mediated oligomerization models, and led to the discovery of novel mechanisms of receptor activation and generation of signaling diversity which are likely to be shared by many different classes of receptors. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 2010