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Neurotrophin receptors: Old friends with new partners
Author(s) -
Schecterson Leslayann C.,
Bothwell Mark
Publication year - 2010
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.20767
Subject(s) - neurotrophin , biology , neuroscience , receptor , tropomyosin receptor kinase a , low affinity nerve growth factor receptor , trk receptor , tropomyosin receptor kinase b , nervous system , neurotrophin 3 , tropomyosin receptor kinase c , neurotrophic factors , microbiology and biotechnology , brain derived neurotrophic factor , genetics , platelet derived growth factor receptor , growth factor
Abstract Neurotrophins are important regulators of embryonic development and adult function of most populations of neurons in vertebrate nervous systems. This signaling system regulates many diverse activities, including survival, axon outgrowth, and synaptic plasticity. In mammals, neurotrophin action is mediated by four receptors, p75 NTR , TrkA, TrkB, and TrkC. Although early studies viewed these receptors as solitary agents in the cells outer membrane, recent discoveries reveal that the cell outer membrane is a crowded and highly interactive neighborhood. Neurotrophin receptors partner with a diverse array of membrane proteins, dramatically expanding their functional repertoire. This review will focus on some of the most recent discoveries concerning the promiscuous partnering of neurotrophin receptors. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 2010