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Glucometabolic state of in‐hospital primary hypertension patients with normal fasting blood glucose in a sub‐population of China
Author(s) -
Chen YangXin,
Fang ChongFeng,
Wang XiaoQiao,
Nie RuQiong,
Li GuoQi,
Tang LiJiang,
Zhou ShuXian,
Wang JingFeng
Publication year - 2009
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.950
Subject(s) - medicine , impaired glucose tolerance , impaired fasting glucose , postprandial , overweight , diabetes mellitus , population , type 2 diabetes mellitus , type 2 diabetes , gastroenterology , endocrinology , obesity , environmental health
Background There is a high prevalence of abnormal glucometabolism (AGM) in patients with coronary heart disease (CHD) and primary hypertension (PH). However, little is known about the glucometabolic state of PH patients with normal fasting blood glucose (FBG). Methods Oral glucose tolerance test (OGTT) was performed for 445 in‐hospital PH patients with normal FBG and re‐performed for those patients with impaired glucose tolerance (IGT) during the follow‐up period. Results Diabetes mellitus (DM), IGT, and AGM (including IGT and DM) accounted for 4.4, 24.5, and 28.9% of patients, respectively. Prevalence of AGM in patients with higher haemoglobin A 1c (HbA 1c ) (≥6.0%), risk factors (CHD, overweight, hyperlipidaemia, proteinuria) was significantly higher than that in patients without these factors. Regression analysis showed that age, overweight, proteinuria, HbA 1c , and CRP were the independent risk factors of AGM. Follow‐up data in 98 IGT patients showed that no improvement of glucometabolism was found, but contrarily, a significant increase of new onset of impaired fasting glucose (IFG) and DM was found after 9 months (P < 0.05), even if diet control and moderate exercise were adopted. Conclusions AGM is prevalent and underestimated in PH patients with normal FBG, and it will develop even if therapeutic life‐style changes are adopted. Except for FBG, more attention should be paid to postprandial blood glucose. OGTT should be a routine procedure for PH patients, especially in‐hospital PH patients, regardless of normal FBG, and active drug intervention for IGT patients with PH may be recommended. Copyright © 2009 John Wiley & Sons, Ltd.