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Rosuvastatin positively changes nerve electrophysiology in diabetic rats
Author(s) -
Tarhzaoui K.,
Valensi P.,
Leger G.,
CohenBoulakia F.,
Lestrade R.,
Behar A.
Publication year - 2009
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.920
Subject(s) - rosuvastatin , nerve conduction velocity , electrophysiology , compound muscle action potential , medicine , tibial nerve , sensory nerve , sensory system , endocrinology , diabetes mellitus , diabetic neuropathy , peripheral neuropathy , anesthesia , neuroscience , psychology , stimulation
Objective To examine the effect of rosuvastatin on peripheral nerve function in diabetic rats using electrophysiological measurements. Background Diabetes was induced in 5‐day‐old male Wistar rats by intraperitoneal (i.p.) injection of streptozotocin (STZ). As many as 45 diabetic rats were randomized to three groups: one treated with rosuvastatin (group R), another with rosuvastatin and mevalonate (group MR) and the other was untreated (group U). The data were compared with a group of normal age‐matched rats i.e. control rats (group C). Methods Neurophysiological measurements were performed at the age of 3 months (T1) and again at the age of 8 months (T2), after 3 months of treatment. Results At T1, there was a trend to lower amplitude of compound motor action potential (CMAP) in the three diabetic groups as compared to controls, and no difference for motor nerve conduction velocity (MNCV), amplitude of sensory nerve action potential (SNAP), sensory nerve conduction velocity (SNCV) between diabetic groups and controls. At T2, the amplitude of CMAP was significantly lower in groups R and MR versus group U and control rats. MNCV was significantly and similarly decreased in the three diabetic groups; the latency of the first sensory peak (fastest sensory fibres) was significantly increased in group U but was normal in groups R and MR. Conclusions This study shows that : 1. rosuvastatin exerts a beneficial effect on the conduction of the fastest sensory fibres; 2. these effects are independent of blood pressure and lipid changes. Copyright © 2009 John Wiley & Sons, Ltd.