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Association of glucose transporter 1 polymorphisms with type 2 diabetes in the Tunisian population
Author(s) -
Makni K.,
Mnif F.,
Boudawara M.,
Hamza N.,
Rekik N.,
Abid M.,
Rebaï A.,
Jarraya F.,
Granier C.,
Ayadi H.
Publication year - 2008
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.866
Subject(s) - haplotype , genetics , single nucleotide polymorphism , genotype , snp , biology , genetic association , glut1 , restriction fragment length polymorphism , type 2 diabetes , gene , glucose transporter , diabetes mellitus , endocrinology , insulin
Abstract Background T2DM is a complex metabolic disease. Genetic studies on T2DM have been of little help so far because several genetic association studies have shown conflicting results. In this study, we report the findings of a case‐control study on three SNPs in the GLUT1 gene. For this, we investigated the association of GLUT1 genotypes and haplotypes with T2DM. Research Design and Methods All 273 T2DM subjects (cases) and 343 healthy subjects (controls) were genotyped using the polymerase chain reaction restriction fragment length polymorphism. Results Results showed that the GT genotype of XbaI SNP could increase the risk of susceptibility to T2DM to 2.4 and that TAT is a ‘risk haplotype’ conferring a risk of 3.4 to T2DM. Conclusion The TAT haplotype of the GLUT1 gene confers susceptibility to T2DM in the Tunisian population. Copyright © 2008 John Wiley & Sons, Ltd.