Insulin effect on serum potassium and auto‐inhibition of insulin secretion is intact in a patient with leprechaunism despite severe impairment of substrates metabolism

Background The effect of insulin on glucose, protein metabolism, circulating fatty acids (FFA), potassium (K + ) and C‐peptide concentrations were investigated in a 12‐year‐old girl with leprechaunism. The mutations do not affect the insulin‐receptor binding affinity and insulin‐stimulated auto‐phosphorylation of the receptor. Methods The subject was studied with a primed‐continuous infusion of [6,6 − 2 H 2 ] glucose and [1‐ 13 C] leucine during a basal period followed by two steps of insulin infusion (1 and 10 mU/kg/min) of 2 h each, during which plasma glucose level decreased from 131 to 115 and then to 95 mg/dL. Results Whole body glucose disposal was virtually unaffected by insulin, slightly decreasing from 21 µmol/kg/min in the basal period to 20 and to 19 µmol/kg/min during the two steps of insulin infusion, respectively. The endogenous leucine flux, an index of proteolysis, was completely insensitive to insulin, being 182, 189 and 180 µmol/kg/min, in the three periods, respectively. The FFA concentration (an indirect index of lipolysis) decreased from 1135 to 799 during step 1. During step 2 the FFA concentration rebounded to 917 µmol/L. The concentration of K + decreased from 4.2 to 3.2 mmol/L and an infusion of 20 mEq/h of KCl was necessary to prevent further hypokalemia (final value 3.3 mmol/l). The C‐peptide concentration declined from 1.85 to 0.97 and then to 0.29 pmol/mL. Conclusions The dissociation of control exerted by insulin on K+ uptake and on β‐cell secretion may rely on a differential expression and folding of the mutated receptors in the different insulin target tissues. Copyright © 2007 John Wiley & Sons, Ltd.