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Sodium selenite protects against diabetes‐induced alterations in the antioxidant defense system of the liver
Author(s) -
Ayaz Murat,
Celik Handan Ak,
Aydin Hikmet Hakan,
Turan Belma
Publication year - 2006
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.601
Subject(s) - glutathione peroxidase , diabetes mellitus , selenium , antioxidant , metallothionein , streptozotocin , medicine , superoxide dismutase , endocrinology , chemistry , lipid peroxidation , glutathione reductase , glutathione , sodium , oxidative stress , pharmacology , biochemistry , enzyme , organic chemistry , gene
Background Free radical genesis of disorder is one of the major subjects of discussion in the explanation of pathological conditions. In this study, the effects of micro molar quantities of sodium selenite treatment on diabetes‐induced alterations in the antioxidant defense system were investigated. Methods Diabetes was induced by administration of streptozotocin (STZ, 50 mg/kg body weight) and both diabetic and control animals were treated with sodium selenite (5 µmol/kg/day) for 4 weeks. Results Our results have shown that induction of diabetes in the liver tissue of animals for 5 weeks resulted in decreased superoxide dismutase (SOD), glutathione reductase (GR) and glutathione peroxidase (GSHPx) activities and concomitantly increased lipid peroxidation (LPO). Conclusion Sodium selenite treatment of the diabetic rats resulted in almost full restoration of all the parameters mentioned above. Metallothionein, which is known to be one of the major antioxidants and a central protein in heavy metal regulation, is altered by diabetes, and sodium selenite treatment restored this alteration as well. Copyright © 2005 John Wiley & Sons, Ltd.