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Gly482Ser polymorphism of the peroxisome proliferator–activated receptor‐γ coactivator‐1 gene might be a risk factor for diabetic retinopathy in Slovene population (Caucasians) with type 2 diabetes and the Pro12Ala polymorphism of the PPARγ gene is not
Author(s) -
Petrovič Mojca Globočnik,
Kunej Tanja,
Peterlin Borut,
Dovč Peter,
Petrovič Daniel
Publication year - 2005
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.546
Subject(s) - diabetic retinopathy , medicine , type 2 diabetes , endocrinology , retinopathy , diabetes mellitus , genotype , population , gene polymorphism , biology , genetics , gene , environmental health
Background The peroxisome proliferator–activated receptor‐gamma ( PPARγ ) gene has been recently associated with type 2 diabetes, obesity and traits depending on VEGF expression (e.g. retinopathy). The PPARγ gene and its coactivator, the peroxisome proliferator–activated receptor‐gamma coactivator‐1 ( PPARGC1 ) gene, have been implicated to be involved in glucose uptake and altered lipid oxidation. We therefore hypothesized that the Gly482Ser polymorphism of the PPARGC1 gene and Pro12Ala polymorphism of the PPARγ gene might confer susceptibility to diabetic retinopathy in type 2 diabetes. The aim of this study was to investigate the association between the Pro12Ala polymorphism in the PPARγ gene and Gly482Ser polymorphism in the PPARGC1 gene and the development of diabetic retinopathy in the Slovene population (Caucasians) with type 2 diabetes. Methods One hundred and sixty subjects with type 2 diabetes and diabetic retinopathy were compared with 101 diabetic subjects without diabetic retinopathy. Chi‐square test was used to compare discrete variables, and continuous clinical data were compared by unpaired students t − test. Results A significantly higher frequency of the AA genotype of the Gly482Ser polymorphism of the PPARGC1 gene was found in the patients with diabetic retinopathy compared to the patients without diabetic retinopathy (14.4% vs 5.9%; p = 0.035), whereas the Pro12Ala polymorphism of the PPARγ gene failed to yield an association with diabetic retinopathy. Conclusions The present study demonstrates that the AA genotype of the Gly482Ser polymorphism in the PPARGC1 gene might be a risk factor for diabetic retinopathy in the Slovene population (Caucasians) with type 2 diabetes (odds ratio 2.7, 95% confidence interval 1.0–6.8), whereas the Pro12Ala polymorphism of the PPARγ gene failed to confer susceptibility to diabetic retinopathy. Copyright © 2005 John Wiley & Sons, Ltd.