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Association between serum leptin concentration and white blood cell count in middle‐aged Japanese men and women
Author(s) -
Mabuchi Tomoko,
Yatsuya Hiroshi,
Tamakoshi Koji,
Otsuka Rei,
Nagasawa Nobue,
Zhang Huiming,
Murata Chiyoe,
Wada Keiko,
Ishikawa Miyuki,
Hori Yoko,
Kondo Takaaki,
Hashimoto Shuji,
Toyoshima Hideaki
Publication year - 2005
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.540
Subject(s) - leptin , white blood cell , medicine , radioimmunoassay , body mass index , endocrinology , proinflammatory cytokine , obesity , inflammation
Background Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans. Methods Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were analyzed in relation to their WBC count. Serum leptin concentrations and WBC counts were measured by radioimmunoassay and automated particle counter respectively, using samples obtained at the time of the participants' annual health checkups. Results The geometric mean (±geometric standard deviation) leptin concentrations were 3.25 ± 1.82 ng/mL and 6.25 ± 3.99 ng/mL, and the geometric mean WBC counts, 5770 ± 1269/mm 3 and 5107 ± 1228/mm 3 , in men and women respectively. The WBC count adjusted for age, body mass index (BMI), physical activity, and drinking and smoking habits increased together with the increase in leptin concentration. Multiple linear regression against WBC count by the leptin concentration and those covariates revealed a significant and independent association with serum leptin concentration especially in women (standardized β = 0.31, p < 0.001), and also in men (standardized β = 0.17, p < 0.001). BMI was not significantly associated with WBC counts in the multivariate model adjusting for leptin levels in both sexes. Conclusions Our results are in line with leptin's hematopoietic or proinflammatory functions. The increased WBC counts often observed in obese people would be mediated by the increased leptin concentration. Copyright © 2005 John Wiley & Sons, Ltd.