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An observational study comparing continuous subcutaneous insulin infusion (CSII) and insulin glargine in children with type 1 diabetes
Author(s) -
Schiaffini Riccardo,
Ciampalini Paolo,
Spera Sabrina,
Cappa Marco,
Crinó Antonino
Publication year - 2004
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.520
Subject(s) - medicine , bedtime , insulin , insulin glargine , type 1 diabetes , diabetes mellitus , pediatrics , endocrinology , type 2 diabetes , regimen , insulin pump , pediatric endocrinology , hypoglycemia
Objective The advantages of continuous subcutaneous insulin infusion (CSII) or insulin glargine have been demonstrated both in adult and paediatric diabetic patients; however, as no data comparing these two approaches during childhood are available, we have examined the efficacy of these two intensive approaches. Research Design and Methods We retrospectively evaluated data from 36 diabetic children, who had changed their previous insulin regimen [with isophane insulin (NPH) at bedtime] because of HbA 1c levels >8.0%. Twenty patients underwent CSII, while the other 16 (significantly younger for age) started insulin glargine at bedtime. Results At 6 and 12 months, CSII‐treated patients showed a significant reduction in HbA 1c values from 8.5 ± 1.8 to 7.4 ± 1.1% and to 7.6 ± 1.2%, respectively. The insulin requirement significantly decreased from 0.93 ± 0.2 IU/kg to 0.73 ± 0.2 IU/kg of body weight and to 0.74 ± 0.15 IU/kg of body weight, respectively, while no significant differences were observed for BMI SDS, fructosamine and severe hypoglycaemic events. The patients treated with glargine showed a small decline in HbA 1c values from 8.9 ± 1.7 to 8.3 ± 0.9% (not significant) in the first 6 months of treatment and to 8.2 ± 0.9% after 12 months. Conclusion The basal insulin supplementation can be supplied effectively in children with type 1 diabetes by either CSII or insulin glargine. As previously reported for adults, it is confirmed that CSII is the best current intensive approach aimed to the improvement of glycaemic control. Copyright © 2004 John Wiley & Sons, Ltd.