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Nocturnal hypoglycaemia in type 1 diabetes—consequences and assessment
Author(s) -
DeVries J. Hans,
Wentholt Iris M. E.,
Masurel Nathalie,
Mantel Itske,
Poscia Alessandro,
Maran Alberto,
Heine Robert J.
Publication year - 2004
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.513
Subject(s) - type 2 diabetes , nocturnal , medicine , diabetes mellitus , type 1 diabetes , endocrinology
Hypoglycaemia is inevitable when striving for low HbA 1 c values. Nocturnal hypoglycaemia often occurs without symptoms, but results in diminished next day well‐being and hypoglycaemia unawareness. Frequency of nocturnal hypoglycaemia was first assessed in research ward settings, but suffered from insufficient glucose sampling frequency. This may have resulted in overestimation of the duration of hypoglycaemic episodes. The advent of the first continuous glucose sensor, the needle‐type MedtronicMiniMed Continuous Glucose Measurement System, revolutionized the assessment of glucose values. However, on scrutiny, the first version of this sensor showed a drift into the hypoglycaemic area and delayed recovery from hypoglycaemia. Using the microdialysis‐based GlucoDay system, our group reported a lower frequency of nocturnal hypoglycaemia in type 1 diabetes patients using an insulin pump, than that expected from the existing literature. Today, more than 80 years after the introduction of insulin for the treatment of type 1 diabetes, the associated frequency of nocturnal hypoglycaemia still awaits its definitive assessment. Copyright © 2004 John Wiley & Sons, Ltd.