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Beneficial effects of aminoguanidine on the cardiovascular system of diabetic rats
Author(s) -
Stadler Krisztián,
Jenei Veronika,
Somogyi Anikó,
Jakus Judit
Publication year - 2005
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.501
Subject(s) - glycation , medicine , protein carbonylation , muscle hypertrophy , diabetes mellitus , endocrinology , cardiac hypertrophy , insulin , streptozotocin , oxidative stress , oxidative damage
Background The study focused on investigating the effect of aminoguanidine on cardiovascular damages in diabetes and the possible mechanisms of its action. Methods Aminoguanidine (AMNG) was used to treat streptozotocin‐induced diabetic rats, and the effects were compared to those obtained under insulin treatment. Blood metabolic parameters, • NO and ONOO − as well as protein carbonyl levels and cardiac hypertrophy were determined. Results Diabetic animals showed increased • NO levels and markedly increased ONOO − generation in the aorta, along with a significant hypertrophy and protein carbonylation in the cardiac tissue. Both AMNG and insulin treatment suppressed the levels of overproduced • NO or ONOO − in the vasculature, but only AMNG was able to prevent hypertrophic alterations and reduce protein carbonylation in the cardiac tissue. Conclusions Oxidative protein modification, together with cardiac hypertrophy and high generation of • NO and ONOO − , are important early events in the development of cardiovascular complications in diabetes. Aminoguanidine could prevent hypertrophy through inhibition of production of nonenzymatic glycation products rather than via inhibition of • NO production. Copyright © 2004 John Wiley & Sons, Ltd.