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Progenitor cells in the adult pancreas
Author(s) -
Holland Andrew M.,
Góñez L. Jorge,
Harrison Leonard C.
Publication year - 2004
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.430
Subject(s) - progenitor cell , stem cell , pancreas , regeneration (biology) , embryonic stem cell , biology , beta cell , microbiology and biotechnology , adult stem cell , progenitor , cellular differentiation , cell type , cell , neuroscience , immunology , diabetes mellitus , endocrinology , genetics , islet , gene
The β‐cell mass in the adult pancreas possesses the ability to undergo limited regeneration following injury. Identifying the progenitor cells involved in this process and understanding the mechanisms leading to their maturation will open new avenues for the treatment of type 1 diabetes. However, despite steady advances in determining the molecular basis of early pancreatic development, the identification of pancreatic stem cells or β‐cell progenitors and the molecular mechanisms underlying β‐cell regeneration remain unclear. Recent advances in the directed differentiation of embryonic and adult stem cells has heightened interest in the possible application of stem cell therapy in the treatment of type 1 diabetes. Drawing on the expanding knowledge of pancreas development, β‐cell regeneration and stem cell research, this review focuses on progenitor cells in the adult pancreas as a potential source of β‐cells. Copyright © 2004 John Wiley & Sons, Ltd.