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CRP and IL‐6 concentrations are associated with poor glycemic control despite preserved β‐cell function during the first year after diagnosis of type 1 diabetes
Author(s) -
Schölin Anna,
Siegbahn Agneta,
Lind Lars,
Berne Christian,
Sundkvist Göran,
Björk Elisabeth,
Karlsson F. Anders
Publication year - 2004
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.427
Subject(s) - medicine , glycemic , autoantibody , islet , type 1 diabetes , diabetes mellitus , c reactive protein , autoimmunity , endocrinology , insulin , insulin resistance , inflammation , gastroenterology , immunology , antibody , disease
Abstract Background The role of non‐specific inflammation in β‐cell loss in type 1 diabetes is unclear. In the present study, inflammatory markers were determined in patients with newly diagnosed disease and related to β‐cell function, glycemic control and autoimmunity. Methods Ninety‐seven adult patients with type 1 diabetes mellitus (80% islet antibody positives, ab + ) were examined at diagnosis and 3, 6, 9 and 12 months after the start of insulin treatment. Plasma C‐reactive protein (CRP), interleukin‐6 (IL‐6), C‐peptide, islet autoantibodies, insulin requirement and HbA 1c were assessed. Results The concentrations of CRP were high‐normal at diagnosis and did not change during the study period. A positive correlation between CRP at diagnosis and BMI was observed in ab + as well as in ab − cases. Detectable concentrations of IL‐6 were found in 32% (157/485) of the samples and did not change during the study. Ab − patients had higher values of CRP at diagnosis and throughout the study compared to the ab + . Among the ab + patients, CRP concentrations during the study were positively correlated to C‐peptide at 12 months and an increase in HbA 1c levels between 6 and 12 months. No associations between the presence or levels of islet autoantibodies and CRP were noted. Conclusions In type 1 diabetes, the islet destructive process and the development of β‐cell remission are not associated with changes in CRP or IL‐6. Instead, elevated CRP concentrations are prevalent and seem to reflect insulin resistance, as positive associations to BMI, C‐peptide and deterioration of glycemic control were observed. Copyright © 2003 John Wiley & Sons, Ltd.