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The role of phospholipase D in Glut‐4 translocation
Author(s) -
Huang Ping,
Frohman Michael A.
Publication year - 2003
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.416
Subject(s) - phospholipase d , microbiology and biotechnology , phosphatidic acid , phospholipase , signal transduction , phospholipase c , chromosomal translocation , vesicle , phosphoinositide phospholipase c , chemistry , second messenger system , biology , biochemistry , phospholipid , enzyme , membrane , gene
Insulin‐stimulated Glut‐4 translocation is regulated through a complex pathway. Increasing attention is being paid to the role undertaken in this process by Phospholipase D, a signal transduction‐activated enzyme that generates the lipid second‐messenger phosphatidic acid. Phospholipase D facilitates Glut‐4 translocation at potentially multiple steps in its outward movement. Current investigation is centered on Phospholipase D promotion of Glut‐4‐containing membrane vesicle trafficking and vesicle fusion into the plasma membrane, in part through activation of atypical protein kinase C isoforms. Copyright © 2003 John Wiley & Sons, Ltd.