Premium
Characteristics and outcomes of COVID ‐19 in hospitalized patients with and without diabetes
Author(s) -
AlSalameh Abdallah,
Lanoix JeanPhilippe,
Bennis Youssef,
Andrejak Claire,
Brochot Etienne,
Deschasse Guillaume,
Dupont Hervé,
Goeb Vincent,
Jaureguy Maité,
Lion Sylvie,
Maizel Julien,
Moyet Julien,
Vaysse Benoit,
Desailloud Rachel,
Ganry Olivier,
Schmit JeanLuc,
Lalau JeanDaniel
Publication year - 2021
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.3388
Subject(s) - covid-19 , diabetes mellitus , medicine , virology , disease , endocrinology , infectious disease (medical specialty) , outbreak
Background Coronavirus disease 2019 (COVID‐19) is a rapidly progressing pandemic, with four million confirmed cases and 280 000 deaths at the time of writing. Some studies have suggested that diabetes is associated with a greater risk of developing severe forms of COVID‐19. The primary objective of the present study was to compare the clinical features and outcomes in hospitalized COVID‐19 patients with vs without diabetes. Methods All consecutive adult patients admitted to Amiens University Hospital (Amiens, France) with confirmed COVID‐19 up until April 21st, 2020, were included. The composite primary endpoint comprised admission to the intensive care unit (ICU) and death. Both components were also analysed separately in a logistic regression analysis and a Cox proportional hazards model. Results A total of 433 patients (median age: 72; 238 (55%) men; diabetes: 115 (26.6%)) were included. Most of the deaths occurred in non‐ICU units and among older adults. Multivariate analyses showed that diabetes was associated neither with the primary endpoint (odds ratio (OR): 1.12; 95% confidence interval (CI): 0.66‐1.90) nor with mortality (hazard ratio: 0.73; 95%CI: 0.40‐1.34) but was associated with ICU admission (OR: 2.06; 95%CI 1.09‐3.92, P = .027) and a longer length of hospital stay. Age was negatively associated with ICU admission and positively associated with death. Conclusions Diabetes was prevalent in a quarter of the patients hospitalized with COVID‐19; it was associated with a greater risk of ICU admission but not with a significant elevation in mortality. Further investigation of the relationship between COVID‐19 severity and diabetes is warranted.