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Adult‐onset type 1 diabetic patients with less severe clinical manifestation have less risk DR‐DQ genotypes than childhood‐onset patients
Author(s) -
Ren Wenqian,
Yang Daizhi,
Jiang Ziyu,
Xian Yingxin,
Huang Qianwen,
Luo Sihui,
Zheng Xueying,
Yan Jinhua,
Xu Wen,
Yao Bin,
Wang CongYi,
Bei JinXin,
Groop Leif,
Noble Janelle A,
Weng Jianping
Publication year - 2021
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.3357
Subject(s) - medicine , age of onset , genotype , type 1 diabetes , diabetes mellitus , cohort , genotyping , haplotype , pediatrics , disease , endocrinology , biology , biochemistry , gene
Background The aim of this study was to investigate differences in clinical features and HLA genotypes between adult‐onset and childhood‐onset patients with type 1 diabetes in a Chinese population. Materials and Methods This study enrolled 716 Han Chinese patients with type 1 diabetes from Guangdong (258 childhood‐onset and 458 adult‐onset) to compare their clinical features. Of them 214 patients with classical type 1 diabetes (100 childhood‐onset and 114 adult‐onset) were selected for HLA DR and DQ genotyping by next‐generation sequencing. Results Adult‐onset patients were characterized by longer duration of symptoms before diagnosis, lower frequency of DKA at disease onset, less frequent autoantibody positivity, higher serum C‐peptide concentrations, and better glycemic control. These findings were replicated in the restricted cohort of 214 patients with classical type 1 diabetes . Compared with childhood‐onset patients, adult‐onset patients had a lower frequency of the DR9 haplotype, as well as lower frequency of high‐risk DR3/DR4 and DR3/DR9 genotypes, but higher frequency of DR3 / DR3 genotype and DR3 /X, DR4 /X or DR9 /X (X, non‐risk) genotypes. Conclusions Adult‐onset type 1 diabetic patients with susceptible haplotypes ( DR3 , DR4 or DR9 ) were more likely to carry protective DR‐DQ haplotypes than childhood‐onset patients, which suggested the association between less risk DR‐DQ genotypes and the less severe clinical manifestation in adult‐onset patients.