Premium
From immunohistological to anatomical alterations of human pancreas in type 1 diabetes: New concepts on the stage
Author(s) -
Nigi Laura,
Maccora Carla,
Dotta Francesco,
Sebastiani Guido
Publication year - 2020
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.3264
Subject(s) - pancreas , islet , endocrine system , pathological , type 1 diabetes , biology , immune system , stage (stratigraphy) , diabetes mellitus , pathology , medicine , bioinformatics , immunology , endocrinology , hormone , paleontology
Summary The histological analysis of human pancreatic samples in type 1 diabetes (T1D) has been proven essential to move forward in the evaluation of in situ events characterizing T1D. Increasing availability of pancreatic tissues collected from diabetic multiorgan donors by centralized biorepositories, which have shared tissues among researchers in the field, has allowed a deeper understanding of T1D pathophysiology, using novel immunohistological and high‐throughput methods. In this review, we provide a comprehensive update of the main recent advancements in the characterization of cellular and molecular events involving endocrine and exocrine pancreas as well as the immune system in the onset and progression of T1D. Additionally, we underline novel elements, which provide evidence that T1D pathological changes affect not only islet β‐cells but also the entire pancreas.