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Osteoarthritis and type 2 diabetes: From pathogenetic factors to therapeutic intervention
Author(s) -
Cannata Francesca,
Vadalà Gianluca,
Ambrosio Luca,
Napoli Nicola,
Papalia Rocco,
Denaro Vincenzo,
Pozzilli Paolo
Publication year - 2020
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.3254
Subject(s) - type 2 diabetes , osteoarthritis , medicine , obesity , population , diabetes mellitus , quality of life (healthcare) , bioinformatics , gerontology , physical therapy , environmental health , alternative medicine , biology , pathology , endocrinology , nursing
Summary Over the last decades, osteoarthritis (OA) and type 2 diabetes (T2D) prevalence increased due to the global ageing population and the pandemic obesity. They currently affect a substantial part of the Western world population and are characterized by enhancing the risk of disability and reduction of quality of life. OA is a multifactorial condition whose development derives from the interaction between individual and environmental factors: The best known primarily include age, female gender, genetic determinants, articular biomechanics, and obesity (OB). Given the high prevalence of OA and T2D and their association with OB and inflammation, several studies have been conducted to investigate the causative role of biological characteristics proper to T2D on the development of OA. This review aims to analyse the relationship between of OA and T2D, in order to explain the pathophysiological drivers of the degenerative process and to delineate possible targets to which appropriate treatments may be addressed in the near future.