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Microangiopathy: Is it relevant to wound healing in diabetic foot disease?
Author(s) -
Sharma Sanjeev,
Schaper Nicolaas,
Rayman Gerry
Publication year - 2020
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.3244
Subject(s) - medicine , diabetes mellitus , microangiopathy , diabetic foot , disease , macrovascular disease , intensive care medicine , population , vascular disease , etiology , pathogenesis , wound healing , bioinformatics , surgery , type 2 diabetes , endocrinology , biology , environmental health
Chronic diabetic complications – both microvascular and macrovascular – have become serious health issues with their increasing prevalence paralleling the dramatic rise of the diabetic population worldwide. Of these complications, foot disease is a major cause of morbidity and mortality, consuming more health care resource than all other complications combined. Diabetic polyneuropathy and peripheral vascular disease constitute the two main risk factors, with trauma and foot infection being the most important initiating factors and contributors to delayed healing. Intracellular oxidative stress mediated by hyperglycaemia along with hypertension, dyslipidaemia and smoking constitute the main pathological processes in the aetiology of both macrovascular and microvascular disease. Whilst the former remains the major cause of overall mortality in diabetes, the role of microangiopathy in the pathogenesis of diabetes foot disease and its contribution to delayed wound healing in diabetes has yet to be fully understood and indeed continues to be debated. This article will review the key findings to date on structural and functional microvascular abnormalities in the diabetic foot skin and consider their contribution to impaired would healing.