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Differential associations of ferritin and 25‐hydroxyvitamin D with fasting glucose and diabetes risk in community dwelling older men
Author(s) -
Carrivick Simon,
Alfonso Helman,
Golledge Jonathan,
Clancy Paula,
Flicker Leon,
Gunton Jenny E.,
Hankey Graeme J.,
Almeida Osvaldo P.,
Norman Paul E.,
Yeap Bu B.
Publication year - 2019
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.3172
Subject(s) - diabetes mellitus , ferritin , medicine , odds ratio , vitamin d and neurology , endocrinology , quartile , confidence interval , incidence (geometry) , impaired fasting glucose , type 2 diabetes , vitamin d deficiency , fasting glucose , gastroenterology , insulin resistance , impaired glucose tolerance , physics , optics
Aims We examined associations of ferritin and 25‐hydroxyvitamin D with fasting glucose and prevalent diabetes in older men. Methods Cross‐sectional analysis of 4153 community‐dwelling men aged 70 to 89 years in Western Australia. Plasma ferritin, 25‐hydroxyvitamin D, and glucose were assayed. Diabetes was ascertained from self‐report, medications, and fasting glucose. Results There were 577 men with diabetes (13.9%). In the whole cohort, ferritin was associated with fasting glucose (0.051 mmol/L per 1 SD increase in ferritin, P = .006) and 25‐hydroxyvitamin D was inversely associated (−0.085 mmol/L per 1 SD, P < .001). Ferritin was not associated with prevalent diabetes (highest vs. lowest quartile; >225 vs <66 μg/L: adjusted odds ratio [OR] 0.97, 95% confidence interval [CI], 0.74‐1.27, P = .83). Higher vitamin D was associated with decreased odds of prevalent diabetes (highest vs lowest quartile; >82 nmol/L vs <53 nmol/L: OR = 0.57, 95% CI = 0.43‐0.75, P < .001). There was no interaction between ferritin and vitamin D on diabetes risk. Conclusions In older men, ferritin is associated with fasting glucose but not prevalent diabetes. Higher 25‐hydroxyvitamin D concentrations are independently associated with lower fasting glucose and reduced risk of diabetes. Clinical trials are required to determine whether interventions, which raise vitamin D concentrations, would reduce incidence of diabetes in this expanding demographic group.