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The association between fasting plasma glucose and all‐cause and cause‐specific mortality by gender: The rural Chinese cohort study
Author(s) -
Liu Leilei,
Chen Xu,
Liu Yu,
Sun Xizhuo,
Yin Zhaoxia,
Li Honghui,
Zhang Ming,
Wang Bingyuan,
Ren Yongcheng,
Zhao Yang,
Liu Dechen,
Zhou Junmei,
Liu Xuejiao,
Zhang Dongdong,
Cheng Cheng,
Liu Feiyan,
Zhou Qionggui,
Xu Qihuan,
Xiong Yihan,
Liu Jiali,
You Ziyang,
Hong Shihao,
Wang Chongjian,
Hu Dongsheng
Publication year - 2019
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.3129
Subject(s) - medicine , hazard ratio , confidence interval , impaired fasting glucose , diabetes mellitus , anthropometry , prospective cohort study , proportional hazards model , cohort , cohort study , fasting glucose , population , endocrinology , type 2 diabetes , impaired glucose tolerance , insulin resistance , environmental health
Background To evaluate the association between fasting plasma glucose (FPG) and mortality by gender. Methods A total of 17 248 eligible participants from a rural Chinese prospective cohort population were included. The same questionnaire interview and anthropometric and laboratory measurements were performed at both baseline (2007‐2008) and follow‐up (2013‐2014). Participants were classified according to baseline FPG and diabetic status by sex. Restricted cubic splines and Cox proportional‐hazards regression models, estimating hazard ratio (HR) and 95% confidence interval (CI), were used to assess the FPG‐mortality relation. Results During the 6‐year follow‐up, 618 men and 489 women died. The FPG‐mortality relation was J shaped for both sexes. For men, risk of all‐cause and noncardiovascular disease (CVD)/noncancer mortality was greater with low fasting glucose (LFG) than with normal fasting glucose (adjusted HR [aHR] 1.60; 95% CI, 1.05‐2.43; and aHR 2.16; 95% CI, 1.15‐4.05). Men with diabetes mellitus (DM) showed increased risk of all‐cause (aHR 2.04; 95% CI, 1.60‐2.60), CVD (aHR 1.98; 95% CI, 1.36‐2.89), and non‐CVD/noncancer mortality (aHR 2.62; 95% CI, 1.76‐3.91). Men with impaired fasting glucose (IFG) had borderline risk of CVD mortality (aHR 1.34; 95% CI, 1.00‐1.79). Women with LFG had increased risk of non‐CVD/noncancer mortality (aHR 2.27; 95% CI, 1.04‐4.95), and women with DM had increased risk of all‐cause (aHR 1.73; 95% CI, 1.35‐2.23), CVD (aHR 1.76; 95% CI, 1.24‐2.50), and non‐CVD/noncancer mortality (aHR 1.97; 95% CI, 1.27‐3.08). Conclusions LFG is positively associated with all‐cause mortality risk in rural Chinese men but not in women.