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Peripheral fat distribution versus waist circumference for predicting mortality in metabolic syndrome
Author(s) -
Wu ChenJung,
Kao TungWei,
Chen YuanYuei,
Yang HuiFang,
Chen WeiLiang
Publication year - 2019
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.3116
Subject(s) - waist , metabolic syndrome , medicine , national health and nutrition examination survey , hazard ratio , insulin resistance , circumference , endocrinology , body mass index , insulin , obesity , population , environmental health , confidence interval , geometry , mathematics
Objective To elucidate whether the peripheral fat (PF)‐combined definition of metabolic syndrome (MetS) would show a better predictive ability for cause‐specific mortality than the common MetS. Methods Data were derived from the National Health and Nutrition Examination Survey from 1999 through 2002. We investigated three types of MetS including waist circumference MetS (WCMetS), PFMetS, and PF‐combined definition of MetS. The main outcome was to evaluate the predictive ability of the newly defined MetS for time to cause‐specific mortality. The secondary outcomes were the relationships between the PF percentage and C‐reactive protein (CRP) and homeostasis model assessment of insulin resistance (HOMA‐IR) to clarify the gender discrepancy. Results For cardiovascular mortality, the adjusted hazard ratios for WCMetS, PFMetS, and PF‐combined definition MetS were 1.867, 1.742, and 2.117, respectively (all P < 0.001). A positive association between PF percentage and CRP in men and a negative correlation between PF percentage and HOMA‐IR in women after adjustment for all variates were found. Conclusions The PF‐combined definition of MetS had a stronger predictive ability for all‐cause and cardiovascular mortality than general MetS. Notably, the PF might have differential gender‐specific health effects on cardiovascular events.