Premium
Glucose homeostasis in statin users—The LIFESTAT study
Author(s) -
Morville Thomas,
Dohlmann Tine,
Kuhlman Anja B.,
Monberg Tine,
Torp Mimmi,
Hartmann Bolette,
Holst Jens J.,
Larsen Steen,
Helge Jørn W.,
Dela Flemming
Publication year - 2019
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.3110
Subject(s) - myalgia , statin , medicine , glucose homeostasis , diabetes mellitus , endocrinology , type 2 diabetes , atorvastatin , glut4 , insulin , glucose uptake , insulin resistance
Background Statins are widely used to lower cholesterol concentrations in both primary and secondary prevention of cardiovascular disease. The treatment increases the risk of muscle pain (myalgia) and of type 2 diabetes. However, the underlying mechanisms remain disputed. Methods We investigated whether statin induced myalgia is coupled to impaired glucose homeostasis using oral glucose tolerance test (OGTT), intravenous glucose tolerance test (IVGTT), and the hyperinsulinemic euglycemic clamp. We performed a cross‐sectional study of statin users without CVD (primary prevention) stratified into a statin myalgic (M; n = 25) and a non‐myalgic (NM; n = 39) group as well as a control group (C; n = 20) consisting of non‐statin users. Results A reduction in the insulin secretion rate during the OGTT was observed in the myalgic group compared with the non‐myalgic group (AUC ISR OGTT , C: 1032 (683 ‐ 1500); M: 922 (678 ‐ 1091); NM: 1089 (933 ‐ 1391) pmol·L −1 ·min (median with 25%‐75% percentiles), but no other measurements indicated impaired β‐cell function. We found no other differences between the three groups for other measurements in the OGTT, IVGTT, and euglycemic clamp. Muscle protein content of GLUT4 and hexokinase II was similar between the three groups. Conclusions We conclude that statin users in primary prevention experiencing myalgia do not have impaired glucose homeostasis compared with other statin users or non‐users. We consider this an important aspect in the dialogue between physician and patient regarding statin treatment and adverse effects.