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Serum uric acid to creatinine ratio correlates with β‐cell function in type 2 diabetes
Author(s) -
Li Minchao,
Gu Liubao,
Yang Jun,
Lou Qinglin
Publication year - 2018
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.3001
Subject(s) - creatinine , renal function , medicine , uric acid , logistic regression , confounding , diabetes mellitus , endocrinology , type 2 diabetes
Background The correlation between serum uric acid (SUA) and β‐cell function remains controversial. The present study aims to use a new index, renal function‐normalized SUA, to observe its correlation with β‐cell function in patients with type 2 diabetes (T2DM). Methods A total of 713 patients with T2DM received standard 75‐g oral glucose tolerance and insulin release test. Renal function‐normalized SUA was calculated using SUA/creatinine and β‐cell function was assessed by HOMA‐B. Binary logistic regression analysis was used to estimate the association between SUA/creatinine and β‐cell function. Results There are positive correlations between SUA/creatinine and HOMA‐B ( r = 0.143, P < 0.001), as well as other indexes of β‐cell function including modified β‐cell function index ( r = 0.104, P = 0.007), InsAUC30 ( r = 0.100, P = 0.008), and InsAUC120 ( r = 0.124, P = 0.001). SUA/creatinine also positively correlates with insulin resistance (HOMA‐IR: r = 0.161, P < 0.001). Moreover, multivariate analysis revealed that SUA/creatinine was significantly associated with preserved β‐cell function, independently of potential confounders including sex, BMI, and renal function. Conclusions SUA to creatinine ratio correlates with β‐cell function in T2DM patients.