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Risk of type 2 diabetes in patients with insomnia: A population‐based historical cohort study
Author(s) -
Lin ChiaLing,
Chien WuChien,
Chung ChiHsiang,
Wu FeiLing
Publication year - 2018
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2930
Subject(s) - insomnia , hazard ratio , medicine , cumulative incidence , cohort , proportional hazards model , cohort study , confidence interval , incidence (geometry) , type 2 diabetes mellitus , diabetes mellitus , psychiatry , endocrinology , physics , optics
Background We investigated the risk of type 2 diabetes mellitus (T2DM) in patients with and without insomnia. Methods In this historical cohort study, we performed a secondary analysis of data from 2001 to 2010, which was obtained from Taiwan's National Health Insurance Database. We developed a Cox proportional hazard regression model to estimate the effects of insomnia on T2DM risk. Kaplan‐Meier survival analysis was applied to compare the differences in the cumulative incidence of T2DM between the groups with and without insomnia. Results During the follow‐up period, the T2DM incidence rate of patients with insomnia was significantly higher than that of patients without insomnia (34.7 vs 24.3 per 1000 person‐years). Overall, patients with insomnia had a higher risk of T2DM than did patients without insomnia (adjusted hazard ratio, 1.16; 95% confidence interval [CI], 1.10‐1.19). Among patients aged younger than 40 years, those with insomnia had a higher risk of T2DM than did the comparison cohort (adjusted hazard ratio, 1.31; 95% CI, 1.14‐1.55). Compared with patients without insomnia, the risk tended to increase with the duration of follow‐up in patients with insomnia; when the insomnia duration was <4 years, 4 to 8 years, and >8 years, the risk of T2DM increased by 1.14, 1.38, and 1.51 times (95% CI, 1.03‐1.17, 1.15‐1.49, and 1.20‐1.86), respectively. Patients with insomnia had a higher risk of T2DM, and this risk was particularly pronounced among the younger (≤40 years) population. Conclusion Chronic insomnia could be an important risk factor for T2DM.