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Dysregulation of wound healing mechanisms in diabetes and the importance of negative pressure wound therapy (NPWT)
Author(s) -
Khamaisi Mogher,
Balanson Sarit
Publication year - 2017
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2929
Subject(s) - negative pressure wound therapy , medicine , wound healing , diabetic foot , diabetes mellitus , amputation , intensive care medicine , disease , surgery , alternative medicine , pathology , endocrinology
Diabetes is a serious disease with severe side effects and comorbidities. Diabetic foot with its chronic nonhealing ulcers, or diabetic foot ulcers, as they are commonly called, can be devastating, even leading to amputation. Many therapies exist to assist and improve wound healing. One exciting discovery is the use of negative pressure wound therapy (NPWT) as an adjunct to standard treatment. Few studies have substantively explored the molecular mechanisms of NPWT and why we see improved wound healing, a concept that demands more research. The following commentary summarizes the current literature regarding NPWT as well as some of the vast body of work that focuses on the physiologic mechanisms of wound healing in diabetics in general.