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Comparative evaluation of probiotics effects on plasma glucose, lipid, and insulin levels in streptozotocin‐induced diabetic rats
Author(s) -
Memarrast Faeghe,
GhafouriFard Soudeh,
Kolivand Sedighe,
JafaryNodooshan Saeedeh,
Neyazi Nadia,
Sadroddiny Esmaeil,
Motevaseli Elahe
Publication year - 2017
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2912
Subject(s) - lactobacillus reuteri , medicine , endocrinology , diabetes mellitus , adipose tissue , insulin resistance , streptozotocin , insulin , lactobacillus crispatus , metformin , biology , lactobacillus , food science , fermentation
Background Diabetes is a chronic disorder caused by the relative decrease in insulin production from the pancreas, tissue resistance to insulin, or both. Daily consumption of probiotics, particularly Lactobacilli , has been proposed as a new strategy for prevention or control of diabetes. Methods In the current study, the effects of various probiotics including Lactobacillus reuteri ( L reuteri ), Lactobacillus crispatus ( L crispatus ), and Bacillus subtilis on the levels of blood glucose, lipid, and insulin as well as haemoglobin A 1c (HbA 1c ) were investigated in rat models of streptozotocin (STZ)‐induced diabetes and compared with metformin. In addition, GLUT‐4 and PPAR‐γ transcript levels have been analysed in adipose tissues. Results A significant decrease in plasma glucose and HbA 1c levels and a dramatic increase in insulin levels have been detected after consumption of probiotics. Furthermore, lipid profiles have been improved. The expression of Glut‐4 and Ppar‐γ genes in adipose tissues also increased after treatment period. Conclusion The results of this experiment showed that daily consumption of probiotics can be effective in control of STZ‐induced diabetes and its complications.