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Serum uric acid levels are associated with increased risk of newly developed diabetic retinopathy among Japanese male patients with type 2 diabetes: A prospective cohort study (diabetes distress and care registry at Tenri [ DDCRT 13])
Author(s) -
Kuwata Hirohito,
Okamura Shintaro,
Hayashino Yasuaki,
Tsujii Satoru,
Ishii Hitoshi
Publication year - 2017
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2905
Subject(s) - medicine , diabetes mellitus , diabetic retinopathy , prospective cohort study , type 2 diabetes , united kingdom prospective diabetes study , distress , uric acid , retinopathy , cohort study , cohort , pediatrics , endocrinology , clinical psychology
Objective We assessed the prospective association between baseline serum uric acid levels and consequent risk of developing diabetic retinopathy. Research Design and Methods Data for 1839 type 2 diabetes patients without diabetic retinopathy were obtained from a Japanese diabetes registry. A Cox proportional hazards model with time‐varying exposure information by sex was used and adjusted for potential confounders to assess the independent correlations between baseline serum uric acid levels and incidence rate of diabetic retinopathy. Results Newly developed diabetic retinopathy was recognized in 188 patients (10.2%) during the observation period of 2 years. Compared to the first serum uric acid quartile level, the multivariate adjusted hazards ratio for diabetic retinopathy development in male patients was 1.97 (95% CI, 1.14‐3.41; P = .015), 1.92 (95% CI, 1.18‐3.13; P = .008), and 2.17 (95% CI, 1.40‐3.37; P = .001) for the second, third, and fourth serum uric acid quartile levels, respectively. But this was not the case with female patients. Conclusion Higher serum uric acid levels were associated with increased risk of developing diabetic retinopathy in male patients with type 2 diabetes, but not in female patients. Serum uric acid may be a useful biomarker for predicting the future risk of developing diabetic retinopathy in male patients with type 2 diabetes.