Commentary: Mitochondrial DNA damage and loss in diabetes | Zendy

Gilkerson Robert | Zendy

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Commentary: Mitochondrial DNA damage and loss in diabetes

Author(s) -

Gilkerson Robert

Publication year - 2016

Publication title -

diabetes/metabolism research and reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.307

H-Index - 110

eISSN - 1520-7560

pISSN - 1520-7552

DOI - 10.1002/dmrr.2833

Subject(s) - mitochondrial dna , diabetes mellitus , type 2 diabetes , dna damage , insulin resistance , mitochondrion , disease , genetics , biology , bioinformatics , medicine , dna , computational biology , endocrinology , gene

This commentary discusses damage and loss of mitochondrial DNA (mtDNA) in type 2 diabetes mellitus from both the clinical and experimental perspectives. Increasingly, an array of studies in experimental models and patients suggests that the cellular stresses of insulin resistance in type 2 diabetes damage mtDNA, leading to loss of mitochondrial genetic content. As such, mtDNA is emerging as both a valuable monitoring tool and translational preventive target for metabolic disease. Copyright © 2016 John Wiley & Sons, Ltd.

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