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Commentary: Mitochondrial DNA damage and loss in diabetes
Author(s) -
Gilkerson Robert
Publication year - 2016
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2833
Subject(s) - mitochondrial dna , diabetes mellitus , dna damage , type 2 diabetes , insulin resistance , mitochondrion , disease , genetics , dna damage repair , biology , medicine , bioinformatics , dna , endocrinology , gene
This commentary discusses damage and loss of mitochondrial DNA (mtDNA) in type 2 diabetes mellitus from both the clinical and experimental perspectives. Increasingly, an array of studies in experimental models and patients suggests that the cellular stresses of insulin resistance in type 2 diabetes damage mtDNA, leading to loss of mitochondrial genetic content. As such, mtDNA is emerging as both a valuable monitoring tool and translational preventive target for metabolic disease. Copyright © 2016 John Wiley & Sons, Ltd.