Premium
Differential association of body mass index on glycemic control in type 1 diabetes
Author(s) -
Lee Eun Young,
Lee Yongho,
Jin SangMan,
Yang Hae Kyung,
Jung Chang Hee,
Park CheolYoung,
Cho Jae Hyoung,
Lee Woo Je,
Lee ByungWan,
Kim Jae Hyeon
Publication year - 2017
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2815
Subject(s) - body mass index , medicine , glycemic , diabetes mellitus , type 2 diabetes , observational study , type 1 diabetes , endocrinology
Background In contrast to type 2 diabetes, the association of body mass index (BMI) with glycemic control in type 1 diabetes (T1D) remains unclear. We investigated the relationship between BMI and average HbA 1c levels in subjects with T1D. Method In this multi‐centre observational study, we analysed 719 subjects with T1D aged ≥18 years. Average HbA 1c levels over 18 months and other clinical and laboratory parameters were evaluated. Results The mean age and duration of diabetes at baseline were 41.5 ± 13.9 and 11.3 ± 8.7 years, respectively. A U‐shaped correlation between BMI and 18‐month average HbA 1c levels was documented by a spline curve. Based on this finding, subjects were divided into three groups according to BMI (group I, <21; group II, 21–23; and group III, ≥23 kg/m 2 ). In group I, the BMI negatively correlated with average HbA 1c ( r = −0.172, p = 0.011), while a positive relationship was observed ( r = 0.162, p = 0.012) in group III. Average HbA 1c levels were lower and the proportion of individuals with well‐controlled glycemia (HbA 1c <7%) were increased in the higher BMI tertile group among subjects with group I as well as in the lower BMI tertile group among subjects with group III BMI. After adjustment with additional covariates in the multiple regression model, these associations between BMI and HbA 1c levels according to the different BMI ranges remained significant. Conclusions In Korean subjects with T1D, an inverse relationship of BMI with HbA 1c levels was observed in the low BMI group, while a positive correlation was shown in the high BMI group. Copyright © 2016 John Wiley & Sons, Ltd.