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Association between uric acid, cancer incidence and mortality in patients with type 2 diabetes: Shanghai diabetes registry study
Author(s) -
Deng Zixuan,
Gu Yunjuan,
Hou Xuhong,
Zhang Lei,
Bao Yuqian,
Hu Cheng,
Jia Weiping
Publication year - 2016
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2724
Subject(s) - medicine , diabetes mellitus , incidence (geometry) , cancer , uric acid , type 2 diabetes , cancer registry , gastroenterology , mortality rate , proportional hazards model , endocrinology , physics , optics
Background An elevated serum uric acid level has often been observed with type 2 diabetes or cancer progression. This study aimed to investigate the association between the serum uric acid, cancer incidence, and mortality in Chinese patients with type 2 diabetes. Methods A total of 8274 patients with type 2 diabetes from the Shanghai Diabetes Registry (SDR) participated. The follow‐up rate was 85.4%. All subjects were divided into four groups according to the serum uric acid concentration: group 1 (1.0 mg/dL ≤ SUA < 3.0 mg/dL), group 2 (3.0 mg/dL ≤ SUA <5.0 mg/dL), group 3 (5.0 mg/dL ≤ SUA < 7.0 mg/dL), and group 4 (SUA ≥ 7.0 mg/dL). The primary outcome was the first diagnosis of any cancer. The secondary outcome was all‐cause mortality. A Cox proportional hazards model was used to estimate the relative risks of cancer and death. Results One hundred thirty‐seven men and 115 women had cancer by the end of the study. In women, group 1 had the lowest incidence rate of cancer at 30.3 cases per 10 000 person‐years, followed by group 2 (48.2). The cancer incidence rates in groups 3 (80.4) and 4 (100.8) were significantly higher than in group 2 ( p < 0.05). No significant differences were observed in the incidence of cancer in men ( p = 0.76). The risks of overall mortality and death from cancer were not significantly different among the different serum uric acid groups in either sex ( Pmale = 0.480, Pfemale = 0.075). Conclusion In Chinese female diabetic patients, the incidence of cancer increased with serum uric acid levels. Copyright © 2015 John Wiley & Sons, Ltd.