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Positive correlation of plasma PCSK9 levels with HbA 1c in patients with type 2 diabetes
Author(s) -
Yang ShengHua,
Li Sha,
Zhang Yan,
Xu RuiXia,
Guo YuanLin,
Zhu ChengGang,
Wu NaQiong,
Cui ChuanJue,
Sun Jing,
Li JianJun
Publication year - 2016
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2712
Subject(s) - pcsk9 , medicine , diabetes mellitus , kexin , type 2 diabetes mellitus , type 2 diabetes , endocrinology , cholesterol , gastroenterology , lipoprotein , ldl receptor
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been demonstrated to be involved in not only lipid metabolism but also glucose homeostasis. Glycated haemoglobin (HbA 1c ) is a ‘gold standard’ for monitoring long‐term glycaemic control. However, the correlation of plasma PCSK9 levels with HbA 1c remains undetermined. Methods We consecutively enrolled 805 subjects undergoing coronary angiography, including 176 patients with type 2 diabetes mellitus (T2DM) and 629 non‐diabetic patients. The baseline characteristics were collected, and serum PCSK9 level was assessed by ELISA. Univariable regression analysis and multiple‐variable regression analysis were used to examine the associations of PCSK9 with HbA 1c . Furthermore, the HbA 1c was compared across the tertiles of PCSK9 levels. And also, PCSK9 levels were compared in poorly controlled (HbA 1c ≥ 7.0%) and well‐controlled (HbA 1c < 7.0%) patients with T2DM. Results PCSK9 levels were positively correlated with low‐density lipoprotein cholesterol in both T2DM and non‐T2DM. Univariable regression analysis revealed a positive association between PCSK9 and HbA 1c in patients with T2DM ( β = 0.255, p = 0.001) but not in patients without diabetes ( β = 0.061, p = 0.128). Multiple‐variable regression analysis exhibited that PCSK9 was independently correlated with HbA 1c in T2DM after adjustment for traditional atherosclerotic risk factors ( β = 0.197, p = 0.020). Moreover, HbA 1c level was higher in patients with the highest tertile of PCSK9 than that in the lowest tertile ( p = 0.042). Additionally, higher levels of PCSK9 were found in poorly controlled group compared with the well‐controlled group ( p = 0.029). Conclusions Data suggest a positive correlation of PCSK9 levels with HbA 1c in patients with T2DM but not in patients without T2DM, indicating a potential role of PCSK9 in T2DM. Copyright © 2015 John Wiley & Sons, Ltd.