Premium
Association of polymorphisms in IL6 gene promoter region with type 1 diabetes and increased albumin‐to‐creatinine ratio
Author(s) -
Ururahy Marcela Abbott Galvão,
Souza Karla Simone Costa,
Oliveira Yonara Monique da Costa,
Loureiro Melina Bezerra,
Silva Heglayne Pereira Vital,
FreireNeto Francisco Paulo,
Bezerra João Felipe,
Luchessi André Ducati,
Doi Sonia Quateli,
Hirata Rosario Dominguez Crespo,
Almeida Maria das Graças,
Arrais Ricardo Fernando,
Hirata Mario Hiroyuki,
Rezende Adriana Augusto
Publication year - 2015
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2621
Subject(s) - medicine , creatinine , endocrinology , glycemic , diabetic nephropathy , type 1 diabetes , diabetes mellitus , glycated hemoglobin , renal function , type 2 diabetes mellitus , nephropathy , lipid profile , albumin , cholesterol , type 2 diabetes , gastroenterology
Background Pro‐inflammatory cytokines, such as interleukin‐6 (IL‐6), have been considered as key factors in type 1 diabetes mellitus (T1DM) and diabetic nephropathy, thus, our aim was to investigate the association of IL6 ‐174G>C (rs1800795) and ‐634C>G (rs1800796) polymorphisms with T1DM susceptibility and diabetic nephropathy. Methods These polymorphisms were analyzed in 144 children and adolescents with T1DM and 173 normoglycemic control subjects. Glycemic control, laboratory parameters of kidney function and serum lipids were evaluated. By studying only T1DM patients, we evaluated the polymorphisms associated with relevant biochemical parameters in various genetic models. Results Type 1 diabetes mellitus patients showed poor glycemic control and albumin‐to‐creatinine ratio, total cholesterol and LDL‐cholesterol levels increased when compared with normoglycemic subjects ( p < 0.001, p = 0.004 and p < 0.001, respectively). IL6 ‐174C allele was associated with an increased risk of developing T1DM (OR = 1.53, CI = 1.01‐2.31, p = 0.044). In the T1DM group, IL6 ‐174CC carriers showed higher concentrations of glycated hemoglobin ( p = 0.029), albumin‐to‐creatinine ratio ( p = 0.021), total cholesterol ( p = 0.010), and LDL‐cholesterol ( p = 0.002), when compared with GG+GC carriers. No association was found for the IL6 ‐634C>G polymorphism. Conclusions These results suggest that IL6 ‐174G>C may contribute to T1DM and increased albumin‐to‐creatinine ratio as well as to poor glycemic control and hyperlipidemia. Copyright © 2014 John Wiley & Sons, Ltd.