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The role of increased liver triglyceride content: a culprit of diabetic hyperglycaemia?
Author(s) -
Song Shaoming
Publication year - 2002
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.260
Subject(s) - insulin resistance , lipodystrophy , type 2 diabetes , diabetes mellitus , endocrinology , medicine , steatosis , obesity , insulin , etiology , pathogenesis , triglyceride , type 2 diabetes mellitus , lipotoxicity , cholesterol , immunology , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy
Abstract The role of fat in the aetiology of insulin resistance and type 2 diabetes has been re‐considered in the present review. This is because of the questions raised by recent created mouse models imitating human lipodystrophy diabetes. It appears that hepatic steatosis, which is shared by both lipodystrophy and most if not all obesity patients, may play a key role in the pathogenesis of insulin resistance and type 2 diabetes despite the fact that lipodystrophy is an extreme state and occurs more rarely than obesity. The possible link between lipid and glucose metabolisms via peroxisome activity has been examined and its role in determining hyperglycaemia is suggested. Moreover, new avenues towards a better understanding of insulin resistance at the genomic level have also been proposed. It appears that one of the most fundamental biological phenomena, fuel selection, may underlie the causes of diabetic hyperglycaemia and perplex the role of fat in the aetiology of insulin resistance. Copyright © 2002 John Wiley & Sons, Ltd.