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The trajectory of IGF‐1 across age and duration of type 1 diabetes
Author(s) -
Palta Mari,
LeCaire Tamara J.,
SadekBadawi Mona,
Herrera Victor M.,
Danielson Kirstie K.
Publication year - 2014
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2554
Subject(s) - diabetes mellitus , medicine , type 2 diabetes , type 1 diabetes , demography , cohort , longitudinal study , insulin resistance , cohort study , normative , insulin , age of onset , endocrinology , disease , philosophy , epistemology , pathology , sociology
Background Individuals with type 1 diabetes may have low IGF‐1, related to insulinopenia and insulin resistance. There are few longitudinal studies of IGF‐1 levels to establish its pattern in type 1 diabetes with duration and age, and to examine whether IGF‐1 tracks within individuals over time. We examine age and duration trends, and the relationship of IGF‐1 to gender, glycaemic control, insulin level and other factors. Methods Participants in the Wisconsin Diabetes Registry Study, an incident cohort study of type 1 diabetes diagnosed May 1987–April 1992, were followed for up to 18 years with IGF‐1 samples up to age 45 for women and age 37 for men. Results IGF‐1 is lower with type 1 diabetes than in normative samples. Although, the pattern across age resembles that in normative samples with a peak in adolescence and slow decline after age 20, the adolescent peak is delayed for women with type 1 diabetes. There was low to moderate tracking of IGF‐1 within an individual. Higher insulin dose was associated with higher IGF‐1 as was puberty, and female gender. Adjusted for these factors, IGF‐1 declined rapidly across early diabetes duration. Lower HbA1c was most strongly related to higher IGF‐1 at Tanner stages 1 and 2. Conclusions IGF‐1 is low in type 1 diabetes, with a delayed adolescent peak in women and is especially influenced by glycaemic control in early and pre‐adolescence. High variability within an individual is likely a challenge in investigating associations between IGF‐1 and long‐term outcomes, and may explain contradictory findings. Copyright © 2014 John Wiley & Sons, Ltd.