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Relationship between gestational fasting plasma glucose and neonatal birth weight, prenatal blood pressure and dystocia in pregnant Chinese women
Author(s) -
Zhu Min,
Cai Jing,
Liu Shujuan,
Huang Mingwei,
Chen Yao,
Lai Xiaolan,
Chen Yuyu,
Zhao Zhongwen,
Wu Fangzhen,
Wu Dongmei,
Miu Haiyan,
Lai Shenghan,
Chen Gang
Publication year - 2014
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2544
Subject(s) - medicine , gestational diabetes , gestational age , obstetrics , birth weight , pregnancy , endocrinology , plasma glucose , gestation , blood pressure , fetus , diabetes mellitus , biology , genetics
Background Little is known about the optimal cut‐off point of fasting plasma glucose for the diagnosis of gestational diabetes mellitus for pregnant Chinese women. This study investigates the relationship between gestational fasting plasma glucose and several variables: neonatal birth weight, prenatal blood pressure and dystocia rate of pregnant women. In this study, we hoped to provide a useful tool to screen gestational diabetes mellitus in pregnant Chinese women. Methods For 1058 pregnant women enrolled in our hospital at pregnancy weeks 22–30, fasting plasma glucose, neonatal birth weight and prenatal blood pressure, as well as dystocia conditions, were examined. We analysed the correlations between the following: gestational fasting plasma glucose and neonatal birth weight; prenatal blood pressure and gestational fasting plasma glucose as well as dystocia rate and gestational fasting plasma glucose group. Results A modest correlation was observed between gestational fasting plasma glucose and neonatal birth weight ( r = 0.093, p = 0.003). The macrosomia rate was smallest when the gestational fasting plasma glucose was in the range 3.51–5.5 mmol/L. Prenatal blood pressure increased linearly with increasing gestational fasting plasma glucose ( p = 0.000). There was a significant difference between the dystocia rates in different fasting plasma glucose groups (chi‐squared = 13.015, p = 0.043). The results showed that the dystocia rate significantly increased when gestational fasting plasma glucose was >4.9 mmol/L; p = 0.03, OR = 2.156 (95% CI, 1.077–4.318). Conclusion We suggest that the optimal range of gestational fasting plasma glucose for pregnant Chinese women is in the range 3.5–4.9 mmol/L. Copyright © 2014 John Wiley & Sons, Ltd.